Electrospray And Maldi Mass Spectrometry Ebook PDF (2023)

• Author : Richard B. Cole
• Publisher : John Wiley & Sons
• Pages : 847
• Relase : 2011-09-26
• ISBN : 9781118211557
• Rating : 4/5 (411 users)

Electrospray and MALDI Mass Spectrometry by Richard B. Cole Book PDF

Discover how advances in mass spectrometry are fueling newdiscoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteranpractitioners and beginning scientists up to date with the mostrecent trends and findings in electrospray ionization andmatrix-assisted laser desorption/ionization (MALDI) massspectrometry. In particular, this Second Edition highlights howadvances in electrospray and MALDI mass spectrometry are supportingimportant discoveries in new and emerging fields such as proteomicsand metabolomics as well as in traditional areas of chemistry andphysics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION isdivided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomenaunderlying the electrospray process, including selectivity inionization and inherent electrochemistry, and concludes with achapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms,instrument development, and matrix selection, and includes a finalchapter that explores the special application of MALDI to obtaintwo-dimensional images of spatial distributions of compounds onsurfaces Part C, ES and MALDI Coupling to Mass SpectrometryInstrumentation, examines the coupling of these ionizationtechniques to various mass analyzers, including quadrupole iontrap, time-of-flight, Fourier transform ion cyclotron resonance,and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigatesanalytical issues including quantification, charge-statedistributions, noncovalent interactions in solution that arepreserved as gas-phase ions, and various means of ion excitation inpreparation for tandem mass spectrometry, and offers a guide to theinterpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines therole of mass spectrometry in such areas as peptide and proteincharacterization, carbohydrate analysis, lipid analysis, and drugdiscovery Written by a team of leading experts, the book not only providesa critical review of the literature, but also presents key conceptsin tutorial fashion to help readers take full advantage of thelatest technological breakthroughs and applications. As a result,Electrospray and MALDI Mass Spectrometry will help researchersfully leverage the power of electrospray and MALDI massspectrometry. The judicious compartmentalization of chapters, andthe pedagogic presentation style throughout, render the book highlysuitable for use as a text for graduate-level courses in advancedmass spectrometry.

• Author : Rainer Cramer
• Publisher : Springer
• Pages : 286
• Relase : 2015-11-09
• ISBN : 9783319048192
• Rating : 4/5 (411 users)

Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry by Rainer Cramer Book PDF

This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics

• Author : Richard B. Cole
• Publisher : Wiley-Interscience
• Pages : 612
• Relase : 1997-05-06
• ISBN : UOM:39015056304408
• Rating : 4/5 (411 users)

Electrospray Ionization Mass Spectrometry by Richard B. Cole Book PDF

Comprehensive, up-to-date coverage of a revolutionary technique Electrospray ionization mass spectrometry (ESI-MS) has completely changed the way physicists, chemists, and biologists view the study of large molecules. The technique derives detailed information about molecular weights and structures from extremely small sample quantities. ESI-MS can create highly charged forms of very high molecular weight compounds, it is naturally compatible with many types of separation techniques, and it allows noncovalent interactions between molecules in solution to be preserved in the gas phase. But many researchers may not use the technique to its full potential because they are unfamiliar with the different perspectives of its underlying processes, the varied approaches to implementation, and the wide-ranging utility of the technique. In this book, Richard B. Cole and an assemblage of leading researchers present a single-volume compilation of different approaches to the understanding and exploitation of ESI-MS. This comprehensive guide: * Examines the physical and chemical aspects of the electrospray process and describes the events involved in ion formation as well as the electro-chemical phenomena that are central to charged droplet formation during the process * Explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole, magnetic, time-of-flight, quadrupole ion trap, and Fourier transform ion cyclotron resonance instruments * Describes recent progress in interfacing ESI with solution-based separation techniques, including liquid chromatography and capillary electrophoresis * Charts the rapid development of ESI applications and categorizes them by compound type: peptides and proteins, nucleic acids and their constituents, carbohydrates and lipids, small molecules related to pharmacology and drug metabolism, and organometallics and inorganic compounds Electrospray Ionization Mass Spectrometry is the indispensable handbook and reference for anyone who wishes to understand, implement, or apply this technique, including researchers in chemistry, metallochemistry, biochemistry, biology, pharmacology, and physics.

• Author : Franz Hillenkamp,Jasna Peter-Katalinic
• Publisher : John Wiley & Sons
• Pages : 365
• Relase : 2007-02-27
• ISBN : 9783527610471
• Rating : 4/5 (411 users)

Maldi MS by Franz Hillenkamp,Jasna Peter-Katalinic Book PDF

The introduction of the matrix-assisted laser desorption ionization technique (MALDI) changed mass spectrometry (MS) into a powerful tool for biomedical analysis that is now widely employed in academic as well as industrial laboratories. The 2002 Nobel Prize was awarded for the development of methods for identification and structure analyses of biological macromolecules. MALDI is one of the two mass spectrometric methods besides Electrospray which is universally used for this purpose. This unique book gives an in-depth description of the many different applications of MALDI MS, along with a detailed discussion of the technology itself. It will be a much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.

• Author : Gary Siuzdak
• Publisher : Elsevier
• Pages : 161
• Relase : 1996-02-12
• ISBN : 9780080535845
• Rating : 4/5 (411 users)

Mass Spectrometry for Biotechnology by Gary Siuzdak Book PDF

If you investigate biological systems and might use mass spectrometry in your research but need to know more about it, this book is for you. It introduces the fundamental concepts of mass spectrometry and how mass spectrometers work. It also presents recent advancements particularly interesting to bio-researchers in an easy-to-understand manner that does not require extensive background in chemistry, math, or physics. Glossary of basic terms Abundant illustrations Examples of applications Practical tips on using mass spectrometric techniques Useful for peptide, protein, oligonucleotide, and carbohydrate analysis Simplified description of mass spectrometry including: Matrix-Assisted Laser Desorption/Ionization (MALDI) Electrospray Ionization (ESI) Fast Atom/Ion Bombardment (FAB)

• Author : TPE. Hollenbeck,G. Siuzdak,RD. Blackledge
• Publisher :
• Pages : 6
• Relase : 1999
• ISBN : OCLC:1251683357
• Rating : 4/5 (411 users)

Electrospray and MALDI Mass Spectrometry in the Identification of Spermicides in Criminal Investigations by TPE. Hollenbeck,G. Siuzdak,RD. Blackledge Book PDF

Electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry have been used to examine evidence in a sexual assault investigation. Because condoms are being used increasingly by sexual assailants and some condom brands include the spermicide nonoxynol-9 (nonylphenoxy polyethoxyethanol) in the lubricant formulation, the recovery, and identification of nonoxynol-9 from evidence items may assist in proving corpus delicti. A method was developed for the recovery of nonoxynol-9 from internal vaginal swabs and for its identification by reverse phase liquid chromatography/electrospray ionization mass spectrometry (LC ESI-MS), nanoelectrospray ionization (nanoESI) mass spectrometry, and high resolution MALDI Fourier transform mass spectrometry (MALDI-FTMS) The method was tested on extracts from precoitus, immediate postcoitus, and four-hours postcoitus vaginal swabs provided by a volunteer whose partner does not normally use condoms, but for this trial used a condom having a water-soluble gel-type lubricant that includes 5% nonoxynol-9 in its formulation. Subsequently, LC ESI-MS was used to identify traces of nonoxynol-9 from the internal vaginal swab of a victim of a sexual assault.

• Author : Séverine Le Gac,Albert Berg
• Publisher : Royal Society of Chemistry
• Pages : 333
• Relase : 2009
• ISBN : 9780854041299
• Rating : 4/5 (411 users)

Miniaturization and Mass Spectrometry by Séverine Le Gac,Albert Berg Book PDF

"The recent explosion in the use of analytical chemistry, particularly in the biological sciences, has led to a need for fast, reliable and highly sensitive tools able to handle small size samples. Miniaturization and Mass Spectrometry illustrates how microfluidics and lab-on-a-chip devices can fulfill the requirement for miniaturized and enhanced analysis. It focuses on one particular technique, mass spectrometry, whose popularity has increased dramatically in the last two decades." "The book starts with an introduction to the coupling of microfluidics to mass spectrometry (MS) techniques. It then goes on to demonstrate the advantages of such a coupling: the MS analysis benefits from improved sample preparation when performed on J chip while MS yields more information on the sample handled on the chip compared to conventional optical detection techniques." "A history on the developments in this field, starting from the off-chip coupling to on-chip ionization, is also provided. Daniel Figeys and Ruedi Aebersold, pioneers in the development of microfiuidic systems for MS analysis, describe the early beginnings of this hyphenated analysis technique." "Solutions to couple microfluidic systems to the two most popular ionization methods, ESI and MALDI, are presented throughout the chapters. Various examples are given of the application of this microfluidics-MS hyphenated analysis technique to proteomics, metabolomics, organic chemistry and forensics." "Coverage is not limited to academic research. The development of commercialized systems and their current use for routine biological analysis are also presented. This book concludes with a future vision of the integration of the mass spectrometer on the chip, as a last step to yield fully portable systems for on-site analysis."--BOOK JACKET.

• Author : Ivory Xingyu Peng
• Publisher :
• Pages : 314
• Relase : 2009
• ISBN : UCLA:L0099916041
• Rating : 4/5 (411 users)

Electrospray-assisted Laser Desorption Ionization Mass Spectrometry for Proteomic Studies by Ivory Xingyu Peng Book PDF

• Author : Tiffany Siegel Porta
• Publisher : Royal Society of Chemistry
• Pages : 541
• Relase : 2021-12-03
• ISBN : 9781839162411
• Rating : 4/5 (411 users)

MALDI Mass Spectrometry Imaging by Tiffany Siegel Porta Book PDF

This book gathers knowledge about matrix-assisted laser desorption ionisation (MALDI) mass spectrometry imaging for postgraduate and professional researchers in academia and in industry where it has direct application to clinical research.

• Author : Oscar Alzate
• Publisher : CRC Press
• Pages : 354
• Relase : 2009-10-26
• ISBN : 1420076264
• Rating : 4/5 (411 users)

Neuroproteomics by Oscar Alzate Book PDF

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we begin to unravel the complex mysteries of neurological diseases that less than a generation ago seemed opaque to our inquiries, if not altogether intractable. Edited by Dr. Oscar Alzate, Neuroproteomics is the newest volume in the CRC Press Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes research and data contributed from all across the world to present an overview of neuroproteomics that is practical and progressive. Bolstered by each new discovery, researchers employing multiple methods of inquiry gain a deeper understanding of the key biological problems related to brain function, brain structure, and the complexity of the nervous system. This in turn is leading to new understanding about diseases of neurological deficit such as Parkinson’s and Alzheimer’s. Approaches discussed in the book include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their own work, leading researchers detail the principles, approaches, and difficulties of the various techniques, demonstrating the questions that neuroproteomics can answer and those it raises. New challenges wait, not the least of which is the identification of potential methods to regulate the structures and functions of key protein interaction networks. Ultimately, those building on the foundation presented here will advance our understanding of the brain and show us ways to abate the suffering caused by neurological and mental diseases.

• Author : Pawel L. Urban,Yu-Chie Chen,Yi-Sheng Wang
• Publisher : John Wiley & Sons
• Pages : 387
• Relase : 2016-03-21
• ISBN : 9781118887325
• Rating : 4/5 (411 users)

Time-Resolved Mass Spectrometry by Pawel L. Urban,Yu-Chie Chen,Yi-Sheng Wang Book PDF

Time is an important factor in physical and natural sciences. It characterizes the progress of chemical and biochemical processes. Mass spectrometry provides the means to study molecular structures by detecting gas-phase ions with the unique mass-to-charge ratios. Time-resolved mass spectrometry (TRMS) allows one to differentiate between chemical states that can be observed sequentially at different time points. Real-time mass spectrometric monitoring enables recording data continuously with a specified temporal resolution. The TRMS approaches – introduced during the past few decades – have shown temporal resolutions ranging from hours down to microseconds and beyond. This text covers the key aspects of TRMS. It introduces ion sources, mass analyzers, and interfaces utilized in time-resolved measurements; discusses the influence of data acquisition and treatment; finally, it reviews most prominent applications of TRMS – in the studies of reaction kinetics and mechanism, physicochemical phenomena, protein structure dynamics, biocatalysis, and metabolic profiling. It will assist science and engineering students to gain a basic understanding of the TRMS concept, and to recognize its usefulness. In addition, it may benefit scientists who conduct molecular studies in the areas of chemistry, physics and biology.

• Author : Robert J. Cotter
• Publisher :
• Pages : 360
• Relase : 1997
• ISBN : STANFORD:36105019289482
• Rating : 4/5 (411 users)

Time-of-flight Mass Spectrometry by Robert J. Cotter Book PDF

This book presents the basic principles of time-of-flight (TOF) mass spectrometry with a strong emphasis on applications in biological research. It describes many innovative techniques, including orthogonal extraction, post source decay, and delayed extraction, and surveys ionization techniques used on TOF mass spectrometers such as electron impact, plasma desorption, SIMS, FAB, laser desorption, MALDI, and electrospray. The book features chapters on applications to peptides/proteins, oligonucleotides, and other biological macromolecules, and examines how techniques might be used in sequencing the human genome.

• Author : Marek Domin,Robert Cody
• Publisher : Royal Society of Chemistry
• Pages : 528
• Relase : 2014-11-25
• ISBN : 9781849739269
• Rating : 4/5 (411 users)

Ambient Ionization Mass Spectrometry by Marek Domin,Robert Cody Book PDF

Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.

• Author : Liang Li
• Publisher : John Wiley & Sons
• Pages : 320
• Relase : 2009-10-22
• ISBN : 9780470567227
• Rating : 4/5 (411 users)

MALDI Mass Spectrometry for Synthetic Polymer Analysis by Liang Li Book PDF

Principles and Practices of Polymer Mass Spectrometry helps readers acquire the skills necessary for selecting the optimal methods, handling samples, analyzing the data, and interpreting the results of the mass spectrometry of polymers. This guide describes the principles of polymer MS and best practices in polymer characterization. It discusses different approaches, including MALDI, ESI, TOF MS, and FT-MS. It provides a guide to developing appropriate sample preparation protocols for different polymers. Complete with examples of applications and experiments, this is an excellent reference for scientists, researchers, graduate students, and others.

• Author : Paul M. Bigwarfe
• Publisher :
• Pages : 514
• Relase : 2003
• ISBN : OCLC:54385789
• Rating : 4/5 (411 users)

Electrospray and MALDI Mass Spectrometry Analysis of Biological and Pharmaceutical Compounds for Proteomics and Drug Discovery by Paul M. Bigwarfe Book PDF

• Author : Franz Hillenkamp,Jasna Peter-Katalinic
• Publisher : John Wiley & Sons
• Pages : 0
• Relase : 2013-12-23
• ISBN : 9783527333318
• Rating : 4/5 (411 users)

MALDI MS by Franz Hillenkamp,Jasna Peter-Katalinic Book PDF

This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics. The option of MALDI-MS for the analysis of polymers and small molecules are also covered in separate chapters, while new to this edition is a section devoted to the interplay of MALDI MS and bioinformatics. A much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.

• Author : Alison E Ashcroft,Frank Sobott
• Publisher : Royal Society of Chemistry
• Pages : 476
• Relase : 2021-11-26
• ISBN : 9781839162893
• Rating : 4/5 (411 users)

Ion Mobility-Mass Spectrometry by Alison E Ashcroft,Frank Sobott Book PDF

Over the last decade, the use of ion mobility separation in combination with mass spectrometry analysis has developed significantly. This technique adds a unique extra dimension enabling the in-depth analysis of a wide range of complex samples in the areas of the chemical and biological sciences. Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and with numerous different commercial platforms to choose from, this book will help the end users understand the practicalities of using different instruments for different ion mobility purposes. The first section provides a detailed account of the fundamentals behind the technique and the current range of available instrumentation. The second section focusses on the wide range of applications that have benefitted from ion mobility – mass spectrometry and includes topics taken from current research in the pharmaceutical, metabolomics, glycomics, and structural molecular biology fields. The book is primarily aimed at researchers, appealing to practising chemists and biochemists, as well as those in the pharmaceutical and medical fields.

• Author : Richard M. Caprioli,A. Malorni,G. Sindona
• Publisher : Springer Science & Business Media
• Pages : 589
• Relase : 2012-12-06
• ISBN : 9789401151658
• Rating : 4/5 (411 users)

Selected Topics in Mass Spectrometry in the Biomolecular Sciences by Richard M. Caprioli,A. Malorni,G. Sindona Book PDF

Many fundamental aspects of the methods used in mass spectrometry are here presented by outstanding scientists, with reference to very recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are presented, together with optimised GC/MS interfacing systems and tools for quantitative analysis. A comprehensive treatment of modern instrumentation for mass analysis and detection is also included. The major part of the book deals with bioanalytical applications to peptides, proteins, oligonucleotides, polysaccharides, lipids and plant metabolites. Several papers are devoted to the evaluation of adduct formation between DNA and carcinogens. Environmental applications are also included, with examples of some specific cases. Fundamentals and applications are treated with the same degree of depth: the first two parts of the book therefore provide a basis for the understanding of the biomolecular applications section. Audience: Ideal for advanced graduate students of chemistry who have learned some basic mass spectrometry. Also useful for Ph.D. students in chemistry, biology and medicine. Of value to researchers in academic and industrial laboratories.

• Author : W. Ens,K.G. Standing,I. Chernushevich
• Publisher : Springer Science & Business Media
• Pages : 354
• Relase : 2013-03-09
• ISBN : 9789401590464
• Rating : 4/5 (411 users)

New Methods for the Study of Biomolecular Complexes by W. Ens,K.G. Standing,I. Chernushevich Book PDF

A NATO Advanced Research Workshop entitled New Methods for the Study of Molecular Aggregates was held at Tbe Lodge at Kananaskis Village, Alberta, Canada from 16 -20 June 1996. In fact the meeting was entirely concerned with the problem of analyzing biomolecular complexes, so the title of these proceedings has been altered to give a more precise description of the content. Tbe workshop was hosted by the time-of-flight group of the Department of Physics at the University of Manitoba, and was attended by 64 participants from around the world. '!\venty-one invited talks were given and 27 papers were presented as posters. Of the 48 contributions, 22 papers (12 orals, 10 posters) are included in these proceedings. Tbe subject of the conference was the investigation of noncovalent biomolecular complexes, with particular focus on the application of mass spectrometry to their characterization. '!\vo new ionization techniques introduced in the late 1980s, electrospray ionization (ES I) and matrix-assisted laser desorptionlionization (MALDI), resulted in a breakthrough in mass spectrometry, enabling its use in molecular weight and primary structure determination of biopolymers larger than 100 kDa. Recently it has been discovered that ESI mass spectrometry mayaiso be used to characterize complexes containing noncovalent interactions, thus opening new perspectives for supramolecular chemistry. ESI mass spectrometry has the advantage that the sampie is introduced from a homogenous solution which can be maintained at near physiological conditions of pR, concentration, and temperature.

• Author : Jürgen H Gross
• Publisher : Springer Science & Business Media
• Pages : 534
• Relase : 2006-04-05
• ISBN : 9783540407393
• Rating : 4/5 (411 users)

Mass Spectrometry by Jürgen H Gross Book PDF

Mass Spectrometry is an ideal textbook for students and professionals as well as newcomers to the field. Starting from the very first principles of gas-phase ion chemistry and isotopic properties, the textbook takes the reader through the design of mass analyzers and ionization methods all the way to mass spectral interpretation and coupling techniques. Step-by-step, the reader learns how mass spectrometry works and what it can do. The book comprises a balanced mixture of practice-oriented information and theoretical background. It features a clear layout and a wealth of high-quality figures. Exercises and solutions are located on the Springer Global Web.